Tadalafil is an effective solution for men with erectile dysfunction. This erectile dysfunction medication is used to achieve a stronger and longer-lasting erection. The main advantage of tadalafil compared to Viagra and other erectile dysfunction medications is its active duration. Tadalafil guarantees a repeated erection for up to 36 hours, which is why it's also referred to as "the weekend pill".
In this article, you will learn everything you need to know about this effective substance.
- What is tadalafil?
- How does tadalafil work?
- History and origin of tadalafil
- How long does tadalafil work?
- Generic tadalafil
- Dosage
- Contraindications
- Possible Side Effects of Tadalafil
- Can tadalafil be obtained without a prescription?
- Why tadalafil and online purchase?
- Summary
What is Tadalafil?
Tadalafil is used to treat erectile dysfunction (ED). The active ingredient, tadalafil, relaxes smooth muscle cells significantly, thereby promoting blood flow to the penis. This contributes to achieving a firm and long-lasting erection, allowing you to enjoy much better sex.
Tadalafil belongs to a group of active substances called PDE-5 inhibitors. Another popular active substance in this group is sildenafil, which was made famous by Viagra.
Tadalafil is used to treat erectile dysfunction and is sold under the trade name Cialis, among others. In our online shop, you can find potency pills with tadalafil in the Cialis Generics category. Generics are cheaper versions of drugs that are introduced to the market after the expiration of the first supplier's patent.
How does Tadalafil Work?
Tadalafil works similarly to sildenafil and vardenafil by blocking the enzyme PDE-5 (phosphodiesterase-5). High activity of the enzyme PDE-5 prevents an erection. If its activity is reduced by inhibitors such as tadalafil, smooth muscle in the penis relaxes, blood flow to the penis increases, and an erection occurs.
By blocking PDE-5, erection occurs more easily and lasts longer. However, sexual stimulation is always necessary. Tadalafil is not an aphrodisiac – it does not help increase libido.
History and Origin of Tadalafil
The development of Tadalafil was significantly influenced by the discovery and success of its predecessor, sildenafil (Viagra).
Sildenafil was the first phosphodiesterase type 5 (PDE5) inhibitor and was originally developed by Pfizer as a potential treatment for hypertension and angina pectoris. However, during clinical trials, its significant effect on improving erections was discovered, leading to its approval in 1998 as a treatment for erectile dysfunction. The success of Viagra in the erectile dysfunction market led to a great interest in further development and research of drugs in the PDE5 inhibitor category.
Tadalafil was developed as competition to sildenafil by the companies ICOS and Eli Lilly. Later, another active substance, vardenafil, developed by Bayer, joined them. Each of these substances has its advantages and specific pharmacological profile.
Numerous studies comparing the effects of these active substances have been conducted. The efficacy of tadalafil and sildenafil is very similar, as indicated by the study "Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis".
This is also confirmed by the article "Comparison of clinical trials with sildenafil, vardenafil, and tadalafil in erectile dysfunction".
"The only advantage of vardenafil over sildenafil is that it does not inhibit phosphodiesterase-6 and thus does not alter colour perception, a rare side effect that sometimes occurs with sildenafil. Tadalafil has a longer duration of action than sildenafil and vardenafil. Tadalafil is similarly effective as sildenafil in treating ED. In comparative studies, men with ED prefer tadalafil to sildenafil (50/100 mg), probably because of its longer duration of action."
How Long does Tadalafil Work?
Generic tadalafil, as products containing tadalafil are called, should be taken at least 30 minutes before sexual intercourse. Tadalafil lasts significantly longer than sildenafil or vardenafil - up to 36 hours, which is why it is also called the "weekend pill".
Sildenafil lasts 4 to 6 hours, vardenafil 8 to 12 hours. During this time, several erections and ejaculations may occur.
The significantly longer duration of action of tadalafil compared to other active substances has also been confirmed by several independent studies. For example, scientists in the study "Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial" confirmed that Tadalafil 20 mg is an effective and well-tolerated treatment for ED, with a response time of up to 36 hours. Thirty-six hours after taking tadalafil, 59.2% of attempted sexual intercourse attempts were successful compared to 28.3% in the placebo group.
Generic Tadalafil
Generic tadalafil has the same chemical structure and effectiveness as the original branded drug (in this case, Cialis, which is the branded name of tadalafil from Eli Lilly).
Generic drugs usually enter the market after the patent for the original branded drug expires. These generic versions typically offer the same efficacy and safety as branded drugs but at a lower cost.
To be approved by regulatory authorities (such as the FDA in the USA), the manufacturer must demonstrate that the generic product is bioequivalent to the original drug, meaning it has the same efficacy, safety, onset, and duration of action compared to the original drug.
Generic tadalafil is essentially a "non-branded" version of tadalafil that offers the same therapeutic benefits as the original branded drug but usually at a lower cost. Similarly, there are also generic versions of sildenafil (Viagra generics) and generic vardenafil (Levitra generics).
Forms of generic tadalafil and their content in preparations
Tadalafil is available in various variants according to the content of the active ingredient:
Tadalafil is also used in combination with dapoxetine for the combined treatment of erectile dysfunction and premature ejaculation. Here, we can highlight Tadapox, which contains 20 mg of tadalafil and 60 mg of dapoxetine.
Among the most popular generic Cialis are:
- Tadalis SX - tablets with 20 mg of tadalafil
- Vidalista 20, Vidalista 40, Vidalista 60, Vidalista CT - products from Centurion Laboratories in 4 variants, which differ in the content of tadalafil
- Tadarise 40 - tablets with 40 mg of tadalafil
- Apcalis Oral Jelly - a gel form of tadalafil, which is consumed orally. The gel form may offer a faster onset of action than traditional tablets because it is more easily and quickly absorbed by the body. Similarly, it is the case with Kamagra Oral Jelly - a popular gel with sildenafil.
Dosage of Tadalafil
The usual dose is 5-20 mg as a single dose, with a recommended initial dose of 10 mg. Depending on tolerance, the dose can be reduced to 5 mg. Do not exceed the maximum daily dose of 20 mg.
Tadalafil can be used either as a single dose, purely before sexual intercourse, or long-term. There are several studies that have examined the long-term effects of tadalafil. These include a study called Long-Term Safety and Tolerability of Tadalafil in the Treatment of Erectile Dysfunction, which concluded that tadalafil at doses of 5, 10 or 20 mg taken as needed up to once a day for 18 to 24 months was safe and well tolerated.
Contraindications
Do not take products with tadalafil, if you:
- are allergic to tadalafil or any other component of this medication.
- have recently experienced a cerebrovascular accident (stroke), heart attack, or if you have low or high blood pressure.
- are taking nitrates (such as nitroglycerin, isosorbide dinitrate) or nitric oxide-releasing medications (such as isoamyl nitrite).
- use medications for angina pectoris (such as nitrates or nitric oxide donors).
- have a severe heart or liver disorder.
- have a rare retinal disorder (such as retinitis pigmentosa) or experience vision loss due to non-arteritic anterior ischemic optic neuropathy (NAION).
- are taking riociguat (for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension).
- are taking alpha-blockers used for high blood pressure or to treat urinary symptoms associated with benign prostatic hyperplasia.
- are taking protease inhibitors for the treatment of AIDS or HIV infection.
- already take another medication for erectile dysfunction.
Warning
Consult your doctor before starting any medications containing tadalafil if you have experienced:
- heart problems
- Peyronie's disease or any other penile deformity
- ulcer disease or bleeding issues (such as hemophilia)
- intolerance to certain sugars (e.g., lactose)
- sickle cell anemia, leukemia, or multiple myeloma
For patients with severe kidney dysfunction, the maximum recommended dose is 10 mg.
Concurrent use of products with tadalafil with other medications requires approval from your treating physician, especially if you are taking ritonavir, saquinavir, ketoconazole, itraconazole, or erythromycin.
Possible Side Effects of Tadalafil
Not every active ingredient has to suit everyone. Sildenafil suits some, Vardenafil suits others and Tadalafil suits others.
During the use of tadalafil-based medications, side effects may occur. They are usually mild to moderate in nature and often have a short duration. The most commonly reported side effects include headache, nausea, digestive difficulties, facial flushing, hot flashes, vision disturbances (blurred vision or so-called blue vision), memory problems, nasal congestion, and dizziness.
Before using any product for potency, always read carefully the package leaflet and all information, especially about contraindications.
Can you Get Tadalafil without a Prescription?
Tadalafil without a prescription can be ordered online in Germany, Austria, Greece, and most European countries without a prescription in the form of Tadalafil generics (Cialis generics). Original Cialis cannot be bought without a prescription. When choosing a seller, make sure to thoroughly check the online shop. Customer reviews on Trustpilot can be very helpful.
Why Tadalafil and online purchase?
If you have erection problems, medications with tadalafil may be a good choice for you. Especially if you are looking for a product with the longest duration of action.
In addition, ordering Tadalafil generics online has even more advantages:
- You don't need a prescription
- You save tens to hundreds of euros compared to Cialis at the pharmacy
- Wide range of products - you can choose products with tadalafil 20 mg, tadalafil 40 mg, or tadalafil 60 mg.
- You can shop conveniently right now, even from your mobile phone.
- You don't explain anything to anyone - the purchase is completely anonymous
- Your order will arrive in just a few days in an anonymous package right to your home.
- We guarantee originality and high quality for all products. Discreet delivery is guaranteed. Get rid of the fear of failure once and for all, order tadalafil generics now.
Summary
Tadalafil is a medication primarily used to treat erectile dysfunction (ED) - one form of impotence. It relaxes smooth muscle cells and promotes blood flow to the penis, aiding in achieving and maintaining an erection. It facilitates and prolongs erection, but sexual stimulation is necessary to achieve it. Its effects can last up to 36 hours, earning it the nickname "weekend pill."
The history of tadalafil is closely linked to the development of sildenafil - tadalafil was developed as a competitive product. In addition to the original drug (Cialis), tadalafil is also available as a generic drug (so-called cialis generics), offering comparable effects at a lower price.
Tadalafil can be taken either as a single dose or long-term. Potential side effects and contraindications should be considered, and any combination with other medications should be consulted with a doctor.
Author: Christian Fischer
Sources:
https://www.dcurology.net/2023/06/07/comparing-tadalafil-generic-cialis-and-sildenafil-generic-viagra/
https://en.wikipedia.org/wiki/Tadalafil
https://reference.medscape.com/drug/adcirca-cialis-tadalafil-342873
https://www.health.harvard.edu/mens-health/should-you-take-a-daily-erectile-dysfunction-pill
https://www.europeanurology.com/article/S0302-2838(04)00237-4/fulltext
https://www.nature.com/articles/nrurol.2011.165
https://www.mayoclinic.org/diseases-conditions/erectile-dysfunction/symptoms-causes/syc-20355776
https://my.clevelandclinic.org/health/diseases/9121-sexual-dysfunction
https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction
https://www.auanet.org/guidelines-and-quality/guidelines/erectile-dysfunction-(ed)-guideline
https://pubmed.ncbi.nlm.nih.gov/?term=smoking+and+erectile+dysfunction
https://www.mayoclinic.org/healthy-lifestyle/mens-health/in-depth/penis-health/art-20046175
